Andrew Luck is retiring from the NFL and the Indianapolis Colts are being cast as longshots in the AFC South and Super Bowl pictures.

Luck informed the team of his decision and will formally announce his retirement Sunday.

The Colts are left to piece together what remains, and NFL oddsmakers believe the sum of the leftover parts is not great.

Previously 12-1 and 15-1 at Bovada and PointsBet, the Colts are now found at 30-1 and worse at all regulated books.

The team’s AFC South odds dipped as well on the word that Jacoby Brissett would take the reins from Luck. Luck took the Colts to the playoffs in the four seasons in which he played all 16 games. The Colts did not make the postseason in the three other seasons.

Brissett is 5-12 overall as a starter.

While Indianapolis is not the same team it was in 2017, when Brissett filled in and went 4-11, he’s not viewed as a top-tier quarterback. Of course, Luck was, but a recent run of injuries — including shoulder and ankle injuries — apparently pushed Luck away from the game.

The result in Indianapolis is likely an extended run of tough luck.