The Dallas Cowboys and Philadelphia Eagles face off for what is nearly an NFC East championship game on Sunday, but they will do so with injury concerns on their minds. The Eagles know that star offensive lineman Lane Johnson will be out. The Cowboys are hoping starting quarterback Dak Prescott will make it through the game. The NFC West is in a similar position as both the San Francisco 49ers and Seattle Seahawks have multiple injuries on their defenses with their showdown set for Week 17. The NFC North could be decided on Monday night … and Minnesota Vikings may have to face the Green Bay Pacers down two running backs. And then there are those fantasy league championships on the line this weekend.

10. Giants QB Daniel Jones
Status: Will start (ankle)
Level of Concern: None
Next Man Up: This one has no bearing on playoff positioning but could officially close the book on the Eli Manning era in New York. When Jones went down earlier this month, Manning stepped in and started the past two games. He led the Giants to a 36-20 win at home against the Miami Dolphins last weekend in what will likely go down as Manning’s final home game in East Rutherford. Jones will now get two more games before heading into an offseason that could see a lot of turnover with the Giants.

9. Steelers WR JuJu Smith-Schuster
Status: Game-time decision (knee)
Level of Concern: Optimistic (with plenty of worry)
Next Man Up: Smith-Schuster has missed four games, but each new week brought a new level of frustration as the receiver seemingly gets closer and closer to playing, only to see something keep him off the field. This week, Smith-Schuster does not even have a game-status designation on the Friday injury report, and practiced in full both Thursday and Friday. However, when talking to the media Friday, he did not sound like someone who was a lock for the Sunday road game against the New York Jets. “I don’t feel 100 percent, but I’m going to see what I can do,” he said.

8. Raiders RB Josh Jacobs
Status: Out (shoulder)
Level of Concern: Moderate
Next Man Up: When Jacobs sat out two weeks ago against the Tennessee Titans, DeAndre Washington stepped in and rushed 53 yards and a touchdown on 14 carries. Last week against the Jacksonville Jaguars, Jacobs was back in the lineup and ran for 89 yards on 24 carries. The Raiders lost both games (their third and fourth consecutive defeats), and now, needing a miracle to make the postseason, the team is holding its star rookie running back out. With road games against the Los Angeles Chargers and Denver Broncos left on the schedule, Jacobs’ absence doesn’t figure to play a role in any playoff hopes, except for those in fantasy leagues.

7. Bills OT Ty Nsekhe
Status: Out (ankle)
Level of Concern: Moderate
Next Man Up: Cody Ford will once again be asked to start at right tackle in Nsekhe’s absence. It’s nothing new, as Nsekhe has been out since he was injured in Week 11, but the Bills have lost only once since he went down. However, that game was against the Baltimore Ravens — by far the best team the Bills have played in that time. And now comes Buffalo’s biggest game of the season. A win at New England on Saturday would create a tie atop the AFC East between the two teams with one week to go. A Patriots win locks Buffalo into a wild-card slot — and a road game to open the playoffs.

6. Buccaneers WR Chris Godwin
Status: Out (hamstring)
Level of Concern: High
Next Man Up: It’s hard to find a team with a less experienced set of options than what the Bucs have at wide receiver. Not only is Godwin out, but fellow Pro Bowl wideout Mike Evans is also out, as is rookie Scotty Miller. And all with hamstring issues, as well. That leaves Jameis Winston — who is leading the NFL in passing yards and carrying fantasy championship hopes across the country this Sunday — with Breshad Perriman, Justin Watson, Ishmael Hyman, Cyril Grayson and Spencer Schnell at receiver. Only Perriman has more than 10 career receptions, while Hyman, Grayson and Schnell have combined for one career catch.

5. 49ers DE Dee Ford, DT Julian Taylor, S Jaquiski Tartt
Status: Out (Ford, quad/hamstring; Taylor, elbow; Tartt, ribs)
Level of Concern: Elevated
Next Man Up: San Francisco is getting cornerbacks Richard Sherman and K’Waun Williams back from injury, but now they have three other defensive players sitting out in a game that could go a long way to determining the team’s playoff seeding. The Los Angeles Rams are coming to town Saturday night, and while the Rams are not the team the 49ers are worried about when it comes to playoff positioning, if Los Angeles’ offense gets rolling, it could make San Francisco’s regular-season finale against Seattle a lot more dicey. When the teams met in Week 6, the 49ers held Rams QB Jared Goff to 78 yards passing and sacked him four times.

4. Seahawks DE Jadeveon Clowney, DB Quandre Diggs
Status: Doubtful (Clowney, core; Diggs, ankle)
Level of Concern: High
Next Man Up: Clowney has been in and out of the lineup since initially sustaining his injury in Week 10. He has missed two games and played in two more but hasn’t had a sack since getting hurt. Diggs, on the other hand, has been healthy (and exceptional) since arriving via trade from Detroit in October. In five games with the Seahawks, Diggs has three interceptions, a forced fumble, a fumble recovery and a touchdown return. If either can’t go Sunday against Arizona, the team certainly will need them in Week 17 against the 49ers with the NFC West, and perhaps the NFC’s No. 1 seed, on the line.

3. Cowboys QB Dak Prescott
Status: No status (shoulder)
Level of Concern: Moderate
Next Man Up: Dallas is hoping next man up isn’t a consideration it will have to entertain Sunday, as Prescott has yet to miss a game (or start) in his four-year career. And this week is the first time he did not practice in full this season (he was listed as limited in practice all week and did not receive an official game-status designation). Prescott hurt his right shoulder in the first quarter last Sunday but played through it as the Cowboys blew out the Rams 44-21. But the pain following the game was enough to warrant an MRI exam, which revealed a sprained AC joint. Should Prescott suddenly not be able to go against the Eagles, Cooper Rush would get the nod.

2. Eagles OT Lane Johnson
Status: Out (ankle)
Level of Concern: High
Next Man Up: Halapoulivaati Vaitai will fill in for Johnson against this week. Last week, the Eagles survived Johnson’s absence to grab a narrow win in Washington and keep pace with the Cowboys in the NFC East. But this time, Vaitai will line up opposite Cowboys pass-rushing specialist DeMarcus Lawrence much of Sunday’s game. Most pundits give the advantage to Dallas and Lawrence, which the Eagles can ill afford as a Cowboys win would give Dallas the NFC East division crown.

1. Vikings RBs Dalvin Cook, Alexander Mattison
Status: Doubtful (Cook, chest; Mattison, ankle)
Level of Concern: High
Next Man Up: The good news for Minnesota is that Cook is backed up by one of the best rookie running backs in the league this season in Mattison. The bad news for the Vikings is that Mattison is also dinged up, and his status for the Monday night game against the Packers is uncertain. (Teams playing Monday do not have to provide a final game status until Saturday.) Should both not go, that would leave Mike Boone and Ameer Abdullah as the primary backs vs. Green Bay in a game carrying the Vikings’ NFC North hopes.