The New York Giants lost rookie safety Xavier McKinney and linebacker David Mayo to serious injuries Wednesday.
Both players were projected starters this season and both are facing significant recovery times.
McKinney, a second-round pick out of Alabama, fractured his left foot and was scheduled for surgery Wednesday afternoon.
The 22-year-old tallied 95 tackles, three sacks and three interceptions in 13 games with the Crimson Tide in 2019.
Mayo, entering his sixth NFL season and second with New York, will have surgery Thursday for a torn meniscus in his left knee.
Mayo, 27, played all 16 games (13 starts) and tied for second on the Giants with a career-high 80 tackles in 2019, including his first two career sacks.