Wide receiver Michael Pittman is out indefinitely after the Indianapolis Colts’ second-round draft pick in 2020 underwent leg surgery Sunday night.

NFL Network reported Monday that Pittman had surgery for compartment syndrome in his leg and might not return until Week 8.

Coach Frank Reich said Pittman reached out to the team’s trainer, who quickly connected Pittman with team doctors and surgery was arranged.

“Michael Pittman suffered a lower leg injury that worsened over night,” Reich said Monday, declining to place a timetable on his return.

“What I know about it is [offensive coordinator] Nick Sirianni had it. His ended up getting infected after he had surgery … and that made it a whole lot worse. It’s a big deal,” Reich said.

NFL Network reported Pittman likely will not be ready to return until after the Colts’ bye week. Indianapolis is off Week 7 and plays at Detroit on Nov. 1 (Week 8).

Indianapolis is without wide receiver Parris Campbell, who was placed on injured reserve with a knee injury following Week 2. Campbell sprained the MCL and PCL in his left knee in the Colts’ win over the Minnesota Vikings. NFL rules mandate Campbell misses at least three games before he can return.

Pittman, the 34th overall pick in the 2020 draft from Southern California, was forced out of the Week 3 win over the New York Jets with an ankle injury. He attempted to return to the game and finished with four receptions for 26 yards.

Pittman has nine catches for 73 yards in three games.