Two key Colts won’t be on the field when Indianapolis visits the Cleveland Browns on Sunday.

Left tackle Anthony Castonzo and middle linebacker Darius Leonard were ruled out for the Week 5 game.

“AC is a unique player. We think he’s a great player,” head coach Frank Reich said Friday.

Leonard is fighting a groin injury. He has 27 tackles this season and leads the NFL’s top-ranked defense.

Castonzo, a 10-year veteran, entered the week with 136 consecutive starts. He’s nursing a rib injury and won’t be available when the Colts attempt to stop Browns defensive end Myles Garrett. Le’Raven Clark, who spelled Castonzo for four snaps last week, is expected to start Sunday.

Garrett had two sacks and a forced fumble at Dallas last week. He has five sacks and 27 QB pressures this season.