The Philadelphia Eagles won the game but may have lost receiver DeSean Jackson and right tackle Lane Johnson to serious injuries in Thursday night’s 22-21 comeback against the New York Giants.

Making his first appearance since Week 3, Jackson caught three passes for 34 yards and rushed once for 12 yards before being tackled awkwardly on a punt return with 2:09 left in the game.

The Eagles fear the three-time Pro Bowl selection has a high-ankle sprain. Jackson posted a photo to his Instagram stories of himself wearing a walking boot on his right leg with the words, “Pray for me y’all!!”

Jackson, 33, by far Philadelphia’s most experienced wideout with more than 10,000 career yards, will reportedly have an MRI on Friday. He missed the previous three games with a hamstring injury.

Johnson, 30, is also having an MRI Friday to determine the extent of his injured knee, according to the Philadelphia Inquirer. The initial diagnosis was a sprained MCL, per the report.

Johnson, a three-time Pro Bowl pick and 2017 first-team All-Pro, has been dealing with ankle issues for most of the season before suffering this latest setback.

The Eagles (2-4-1) host the Dallas Cowboys next Sunday night (Nov. 1) and have their bye in Week 9, giving both players more time to potentially recover and return to the lineup.