Kevin Na and Sean O’Hair hold a one-shot advantage after the first round of the QBE Shootout.

Na and O’Hair hit the ground running at the Tiburon Golf Club in The Ritz-Carlton Golf Resort in Naples, Florida to lead the way from Ryan Palmer and Harold Varner III.

O’Hair and Na teamed up superbly in the scramble format on Friday, combining for a 16-under opening round of 56.

There were two eagles and 12 birdies for the leading duo, who went out in 27 in a blistering start to an event that is being hosted by Australian great Greg Norman.

Varner and Palmer are hot on their heels, sitting second of the 12 teams after coming up with eight birdies on the front nine and another seven after the turn.

Lanto Griffin and Mackenzie Hughes are just two shots adrift of the leading duo along with Harris English and Matt Kuchar.

Australian duo Marc Leishman and Cameron Smith are among three teams who will head into the weekend with the most ground to make up on 10 under.