Arizona Cardinals quarterback Kyler Murray was temporarily knocked out of Sunday’s game against the Los Angeles Rams after sustaining a right ankle injury on the opening drive of the game.

Murray returned in the fourth quarter as the Cardinals attempted to rally from an 18-7 deficit.

Murray was sacked on a third-and-12 play early in the game and the Rams’ Morgan Fox rolled over Murray’s ankle on the play. He went in and out of the Cardinals’ locker room multiple times in the first half but did not return to the field before halftime and did not start the third quarter.

The Cardinals did not officially rule him out of the game at the start of the second half and he felt good enough to return later.

Murray did have availability questions early in the week after he injured his right leg on his final pass attempt of last Sunday’s game against the San Francisco 49ers. He was a full participant in practice by Wednesday, though, and proclaimed himself healthy.

Murray’s injury turned a key game into a battle of the backup quarterbacks. The Rams and Cardinals both entered Sunday knowing a victory would make them playoff eligible.

Chris Streveler, who had never thrown a pass in an NFL game, took over for Murray, going 5 of 9 in the first half with 24 yards passing and a touchdown. The score came on a shirt flip to Jonathan Ward for an 11-yard TD and a 7-0 first-quarter lead.

The Rams gave John Wolford his first NFL action as a replacement for Jared Goff, who needed surgery following a thumb injury last Sunday against the Seattle Seahawks. Wolford threw an interception on his first career pass attempt in the first quarter that led to the Cardinals’ touchdown.

Cardinals linebacker Jordan Hicks, who intercepted Wolford’s first pass, was later lost for the game with a neck injury.