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Jacques Nienaber had previously served as Rassie Erasmus' assistant with South Africa and has now taken the top job.
Jofra Archer was troubled by his elbow in the warm-up for the fourth Test, so Chris Woakes returns as Beuran Hendricks makes his Test bow.
Three early wickets for Suranga Lakmal set the tone as Zimbabwe suffered a 10-wicket defeat to Sri Lanka.
Saracens owner Nigel Wray apologised for his "ill-considered approach" after a report detailed how Saracens fell foul of salary-cap rules.
The mercurial Finn Russell has been punished for a breach of team protocol just nine days before Scotland's first Six Nations game.
Batsman Temba Bavuma was dropped from the South Africa squad after the second Test, but he comes in for Zubayr Hamza in Johannesburg.