Captain Owen Farrell converted all four of England's tries and also kicked three penalties as his side eased past Italy on Friday.
Gregor Townsend may count the cost of injuries from Scotland's final Rugby World Cup warm-up victory over Georgia.
One of the best wings in South African rugby history, World Cup winner Chester Williams died on Friday.
Japan were unable to repeat their shock 2015 Rugby World Cup success over South Africa, largely due to Makazole Mapimpi's hat-trick.
The upcoming Rugby World Cup will mark David Pocock's last matches for the Wallabies.
Ireland have been boosted by the returns of Johnny Sexton, Conor Murray, Keith Earls and Robbie Henshaw for their meeting with Wales.
Wales have rung the changes against Ireland as they finish preparations for the Rugby World Cup.
Though he is not in the Rugby World Cup squad, Joe Marchant will start at centre against Italy in England's final warm-up game.
Ireland's talisman Johnny Sexton says he was "blessed' to overcome a thumb injury in time to make Joe Schmidt's Rugby World Cup squad.