Gregor Townsend has told Scotland to make themselves "a nightmare to deal with" when they tackle Ireland in Dublin in the Six Nations.
England boss Eddie Jones will be without Luke Cowan-Dickie for the trip to France, after 'family reasons' ruled out the Exeter hooker.
Saracens knew they would be relegated at the end of the season, and a 70-point penalty ensures they will finish bottom of the Premiership.
Johnny Sexton and Jordan Larmour have been joined by uncapped number eight Caelan Doris in Ireland's team to face Scotland.
Ed Griffiths agreed to lead Saracens for 12 months but leaves the Premiership club just weeks after embarking on his second spell in charge.
In their first Premiership outing since their automatic relegation was confirmed, Saracens were soundly beaten by London rivals Harlequins.
Top 14 front-runners Lyon won again, while La Rochelle's Arthur Retiere grabbed a hat-trick and Brive left it late.
Rhyno Smith scored twice in the closing stages against Southern Kings to again secure the bragging rights for the Cheetahs.
Exeter Chiefs rallied in the second half against Sale Sharks, but the Premiership leaders still slipped to a first defeat since November.