The upcoming Rugby World Cup will mark David Pocock's last matches for the Wallabies.
Ireland have been boosted by the returns of Johnny Sexton, Conor Murray, Keith Earls and Robbie Henshaw for their meeting with Wales.
Wales have rung the changes against Ireland as they finish preparations for the Rugby World Cup.
Though he is not in the Rugby World Cup squad, Joe Marchant will start at centre against Italy in England's final warm-up game.
Ireland's talisman Johnny Sexton says he was "blessed' to overcome a thumb injury in time to make Joe Schmidt's Rugby World Cup squad.
Hooker Stuart McInally has been selected to captain Scotland in Japan, though Huw Jones was the shock absentee from the squad list.
There was a major shock in Georgia's Rugby World Cup squad announcement, with Mamuka Gorgodze coming out of retirement.