Amid doubts over the health of his left shoulder, Novak Djokovic withstood a spirited showing from Denis Kudla to reach the last 16.
Third seed Karolina Pliskova needed three sets to reach the fourth round but Serena Williams was dominant in progressing to the last 16.
Coco Gauff is the story of the first week of a grand slam once again as she prepares to face Naomi Osaka at Flushing Meadows.
The tennis world will be watching the future of the women's game when Naomi Osaka faces Coco Gauff, says Serena Williams.
Roger Federer made short work of Dan Evans at the US Open, with the beaten Briton complaining about an early start to the third-round match.
Karolina Muchova failed to add the scalp of Serena Williams to her list as the 23-time major champion prevailed in straight sets.
After some struggles in rounds one and two, Roger Federer needed only an hour and 20 minutes to progress from round three.
John McEnroe thinks a victory over the world number one and defending champion would be too much, too soon for Coco Gauff.